Approved Opportunities for Participating in Clinical Research
If you would like to participate in clinical research, please browse the list below for opportunities that you may be eligible for.
Study Location
Rosalind Franklin University – North Chicago, IL
Research Objectives
The purpose of the study is to determine if walking short distances is more tiring for prosthesis users with vs. without diabetes and to determine if information about fatigue during walking can help explain falls by people who use prostheses.
Eligibility Criteria- Adult (above 18 years old)
To participate you must:
- have a unilateral transtibial (below knee) amputation with at least 6 months prosthesis use experience
- use your prosthesis inside and outside your home
- have a well-fitting and functioning prosthesis
- have an active email account or close friend/family member with an account that can receive emails for you
You can not participate if you have:
- active wounds on the residual limb
- progressive neurologic disease (e.g., MS, Parkinson’s Disease)
- pain, cramping or tiredness in the legs or hip muscles while resting
Compensation Details
You will be compensated $25/hour for time spent in the laboratory. You will receive $5 for every survey that you complete. You will be compensated for your travel expenses at the government medical travel rate, which is set at $0.21 per mile for the year 2024.
Enrollment Closes
Sep 1, 2026
Time Commitment
The laboratory component of this study will last about 1.5 hours. After that, you will be asked to complete an online survey every two weeks for the next 6 months. The survey may take up to 10 minutes to complete.
Contact Person
Jessica Rivas | Email: Jessica.rivas@rosalindfranklin.edu | Phone: 224-570-7543
How to Participate
For enrollment or other questions about this study, please contact the Study Coordinator Jessica Rivas by phone or email. Additional information can be found on the Recruitment Flyer.
Study Location
Online only
Research Objectives
This study will help us to understand how both disability and race affected the pregnancy experiences of Black and Hispanic/Latina/Latinx people, which can help improve the pregnancy experience for others.
Eligibility Criteria- Adult (above 18 years old)
- To take part in this study, you must:
- Have a physical or mobility disability.
- Identify as Black/African American or Latinx/Latina/Hispanic.
- Have given birth in the United States in the last 10 years.
- Be able to complete the interview in English or Spanish over Zoom.
- Be between 21 and 55 years of age.
Compensation Details
After completing the interview participants will receive a $50 Amazon gift card.
Enrollment Closes
Jan 31, 2025
Time Commitment
One (1) Zoom interview that will last about one (1) hour.
Contact Person
Janelle Mills | email: pregnancystudy@brandeis.edu | phone: 781-736-3928.
How to Participate
Please contact Janelle Mills or see the recruitment flyer. More information is on our website.
Study Location
Rosalind Franklin University – North Chicago, IL
University of Michigan – Ann Arbor, MI
Research Objectives
The purpose of the study is to determine if the socket trim line (how high the socket goes up on the residual limb) affects the function of the hip in a way that increases the risk of falling. We are also interested in how hip muscle function differs between the amputated and sound (non-amputated) side.
Eligibility Criteria- Adult (above 18 years old)
To participate you must:
- have a unilateral (single-side) transfemoral (above-knee) amputation
- at least six months of experience with your current prosthesis
- have a well-fitting socket
You will not be eligible to participate if you have any of the following:
- active wounds on your residual limb
- active diabetic foot ulcers on your sound limb
- progressive neurologic disease (i.e. neuropathy)
- an artificial hip replacement
- foot or toe amputation on your sound side
- very short residual limb
Compensation Details
Participants will receive between $180-$240. ($20 per hour for 9-12 hours). Testing will be completed over two sessions. Prearranged and prepaid travel is also available.
Enrollment Closes
August 31, 2025
Time Commitment
We expect that testing will take 9-12 hours total, spaced over two sessions.
Contact Person
Jessica Rivas | Email: Jessica.rivas@rosalindfranklin.edu | Phone: 224-570-7543
How to Participate
For enrollment or other questions about this study, please contact the Study Coordinator Jessica Rivas by phone or email. Additional information can be found on the Recruitment Flyer
Study Location
Ann Arbor, MI
Research Objectives
This study will assess the feasibility and reliability of a novel functional assessment where people make a cup of coffee (“Coffee Task”). This task was designed to quantify how easily and accurately prosthesis users can change their hand grasp.
Eligibility Criteria- Adult (above 18 years old)
- Has upper limb amputation at the transradial or transhumeral level
- Has used a multi-grasp prosthesis for at least 2 months
- Proficient in English
Compensation Details
Participants will receive $20/hour at the end of each visit which is expected to last 2 hours. There are two visits in total.
Enrollment Closes
May 31, 2025
Time Commitment
Once consented, participants will come to the lab for two separate visits one week apart which are expected to last approximately 2 hours each.
Contact Person
Kayla Russell-Bertucci, email: kaylarb@umich.edu
How to Participate
See the recruitment flyer for more information! Reach out to our clinical coordinator Kayla Russell-Bertucci at 734-764-3832 or kaylarb@umich.edu.
Study Location
The Center for Bionic Medicine (CBM) at the Shirley Ryan AbilityLab in Chicago, Illinois
Research Objectives
The purpose of this research is to understand how providing power at the knee or ankle individually, or providing power at both the knee and ankle joints of a prosthesis impacts walking for people with above the knee amputations.
Eligibility Criteria
Participants must:
- Be age 18-95
- Have an amputation or limb loss/difference of one leg above the knee
- Have been walking with a definitive prosthesis for at least 6 months
- Be medically cleared by your physician to participate
- Be English speaking
- Weigh less than 250 pounds
Compensation Details
Participants will be compensated $40 for each study visit, plus the cost of parking and transportation to the Shirley Ryan AbilityLab.
Enrollment Closes
Jun 30, 2028
Time Commitment
1-2 visits per week (2-3 hours each), over 8-10 months
Contact Person
CBM@sralab.org or (312) 238-2080
How to Participate
If you are interested in learning more about the study, please contact study personnel at the Center for Bionic Medicine at CBM@sralab.org or call (312) 238-2080. See our Recruitment Flyer for more information.
Study Location
Online Survey
Research Objectives
The objective of this study is to learn more about how individuals with upper limb loss/difference may choose prosthetic devices that are best for them personally or choose not to have any device.
Eligibility Criteria
In order to participate, you must be 18 years old or older and have an upper limb loss/difference at or above the wrist. You do not need to have or use a prosthesis. You will not be asked to undergo any procedures.
Compensation Details
Each participant will receive twenty-five dollars ($25) for completion of the survey which will be sent via US postal mail.
Enrollment Closes
Aug 31, 2026
Time Commitment
Estimated time to complete the online survey is 30-40 minutes
Contact Person
Leslie Wilson, PhD | email: Wilson-UpperLimbStudy@ucsf.edu | phone: 415-990-1012
How to Participate
If you’re interested in more information or ready to take the survey, call or email Dr. Leslie Wilson. You will be provided a unique number and the study survey link.
Study Location
Union Memorial Hospital – Baltimore, MD
University of Michigan – Ann Arbor, MI
Research Objectives
Demonstrate the effectiveness of Regenerative Peripheral Nerve Interface (RPNI) surgery in treating symptomatic neuromas of the hand and digits following amputation using a prospective, observation trial. Determine the improvements in hand function, upper extremity function, and ability to return to work or duty as a result of RPNI surgery.
Eligibility Criteria
- 18 years or older
- History of unilateral digit, multiple digit, or partial hand amputation
- Discrete neuroma pain on clinical exam
- Following standard of care (SOC), confirmation through a local block and/or ultrasound imaging will be performed if indicated
- Must be seen by a hand therapist for at least 6-week trial of desensitization therapy
Compensation Details
Participants will receive $375 (5 visits; $75 per visit)
Enrollment Closes
Aug 31, 2026
Time Commitment
6 months (+/- 2 weeks)
Contact Person
Ashley Bartee | Email: ashley.e.bartee@medstar.net | Phone: 410-554-2687
How to Participate
See recruitment flyer or contact Ashley Bartee.
Study Location
Online Only
Research Objectives
The overall goal of this project is to learn more about the attention or mental effort needed to use a prosthesis (or artificial limb). Our objective for this study is to develop a new questionnaire to measure prosthetic attention. The questionnaire we develop will be made freely available for use in clinical care, research, and education once it is completed.
Eligibility Criteria
- Must be 18 years of age or older
- Must be able to read, write, and understand English
- Must have an amputation or limb difference in one or both legs (at or above the level of the ankle) OR an amputation or limb difference in one or both arms (at or above the level of the wrist)
- Must have no other amputations
- Must have had the most recent amputation at least 6 months ago
- Must use a prosthesis at least 1 day a week (arm prosthesis users) or 4 days a week (leg prosthesis users)
- Must have at least 6 months experience using a prosthesis
Compensation Details
Eligible respondents will be mailed a $40 check about 2-3 weeks after completing the survey.
Enrollment Closes
December 31, 2024
Time Commitment
The survey will take about 30 to 45 minutes to complete.
Contact Person
UWCORR research staff | email: uwcorr@uw.edu | phone: 206-221-2414
How to Participate
Visit our study website (https://attention-study.org) to take the survey. Contact us by email (uwcorr@uw.edu) or phone (800-504-0564) if you would like a paper survey mailed to you.
Study Location
North Carolina State University – Raleigh, NC
Research Objectives
Powered robotic prostheses have the capacity to mimic the motion of biological joints, but do not consistently lead to improved gait performance due to an unoptimized intelligent controller. In this study, we will design different control algorithms for a variety of walking tasks and compare their performance.
This study will require participants to wear their own prosthesis and our experimental powered prosthesis to walk on level ground, ramp/stair ascent/decent, and step over obstacles. These activities are demonstrated on our webpage: https://nrel.bme.unc.edu/.
Eligibility Criteria
- Must be between 18–70 years old
- Must have a unilateral (single-sided) above-knee amputation
- Body weight must not exceed 250 lbs.
- Must use a prosthesis regularly (3+ hours daily)
- Must be able to walk independently without the use of mobility aids ( e.g. canes, walker, crutches)
Compensation Details
- $25 per hour (3-5 sessions, 4 hour max. per session)
- Travel and lodging reimbursement may be available for eligible participants
Enrollment Closes
Mar 5, 2029
Time Commitment
-
3-5 visits each lasting 2-4 hours.
Contact Person
Laura Rohrbaugh | Email: nrel.ncsu@gmail.com | Phone: 919-515-5218
How to Participate
Contact us by email, phone, or visit us online at https://nrel.bme.unc.edu/get-involved/ to fill out our online intake form. We will contact you to discuss what is involved in being a subject for this study and to address any questions or concerns that you may have.
Study Location
University of Michigan – Ann Arbor, MI
Research Objectives
Powered leg prostheses can greatly assist individuals with above-knee amputations, but these devices are currently designed for a limited set of activities. This study aims to validate a new way to control powered prosthetic devices to restore walking ability in many different activities.
The study protocol will require participants to walk with their existing prosthesis and with an experimental powered prosthesis during sit-to-stand, level-ground walking, stair ascent/decent, and stepping over obstacles. This video demonstrates these activities: https://youtu.be/sBC12VDbaes
Eligibility Criteria
Participants may be eligible if they meet all of the following criteria:
- Adults between 18-70 years of age
- Body weight is 250 lbs. or less
- Has a single leg above-knee amputation or limb difference
Compensation Details
- Participants will receive $40 per hour (2-3 sessions, 4 hours each)
- Travel and lodging reimbursement may be available for eligible participants
Enrollment Closes
February 1, 2029
Time Commitment
- Study will involve 2-3 sessions (with the option for additional sessions)
- Each session will take no longer than 4 hours after setup
Contact Person
Robert Gregg, PhD | Email: rdgregg@umich.edu | Phone: 734-763-1156
How to Participate
Interested participants may enroll through the UMHealthResearch web posting here: https://UMHealthResearch.org/studies/HUM00230065. For questions about this study, please email UM-Locolab@umich.edu. Additional information can be found on the Recruitment Flyer.
Study Location
University of Maryland – College Park, MD
Research Objective
To determine if, in comparison to using a standard socket-based transfemoral prosthesis, an osseointegrated prosthesis reduces the metabolic cost of walking, improves the symmetry of walking gait and/or reduces loading of the intact limb and lower back
Eligibility Criteria
We are seeking individuals with unilateral (single leg) above-knee limb loss who walk with a prosthetic limb, either a traditional socket-based prosthesis or an osseointegrated (bone-anchored) prosthesis.
Additional eligibility criteria are:
- Must be between 18-65 years of age
- Must not be diagnosed with hypertension or metabolic syndrome
- At least 18 months since most recent amputation or revision surgery
- Must be cleared medically to walk with no assistance other than a prosthesis
- Must not have any major chronic issues other than limb loss that affect walking ability
- Must have at least six months experience with current prosthesis used for walking
- Must be assigned a K-level 3 or 4
Compensation
- Participants receive $500 cash immediately upon completing the study.
- Additional lodging and travel compensation is available (some restrictions apply)
Enrollment Closes
6/30/2026
Time Commitment
2-hour session (in person)
Contact Person
Ross Miller | Email: rosshm@umd.edu | Phone: 413-259-5667
How to Participate
See recruitment flyer or contact Dr. Ross Miller
Study Location
University of Illinois at Chicago – Chicago, IL
Research Objective
The goal of this project is to assess the feasibility of maximizing user comfort by personalizing parameters of a novel ankle-foot prosthesis. Through this technology, we aim to enhance the understanding of ankle-foot parameters on socket pressure, user comfort, and perceived effort.
Eligibility Criteria
- Adults between 18-75 years of age
- Have single leg limb loss at the transtibial (below-knee) level
- Leg amputation or revision surgery must have occurred at least 1 year ago
- Must have the ability to walk unassisted for 20 minutes without undue fatigue or health risks
- Must have habitual experience using a lower limb prosthesis for at least 6 months
- Must have a comfortable prosthetic socket
Compensation
$100 per visit with parking reimbursement available
Enrollment Closes
01/31/2025
Time Commitment
4 in-person research sessions (2-3 hours per session)
Contact Person
Michael Jacobson | Email: mjacob38@uic.edu | Phone: 630-890-0837
How to Participate
Contact Michael Jacobson
Study Location
- Richmond, VA
- San Antonio, TX
- Travel funds provided
Research Objective
This study will determine how well upper-limb prosthesis users can do everyday activities and compare the abilities of people who use different types of prosthetic systems. We aim to better understand how different types of prostheses and terminal devices compare to each other and to help consumers and clinicians make informed choices about upper limb prosthetic devices.
Eligibility Criteria
- Unilateral, Major Upper Limb Amputation (between the shoulder and wrist)
- Use a Body-Powered, Myoelectric, or Hybrid Prosthesis
- Understand study requirement & informed consent in English without an interpreter
- Must be at least 18 years of age
Compensation
- $90
Enrollment Closes
December 31, 2024
Time Commitment
4-hour session (in-person)
Contact Person
John Davey – Email: John.Davey@va.gov
How to Participate
For more information please view our Recruitment Flyer. To determine if you are eligible, please contact the study Deputy Project Coordinator, John Davey at 401-273-7100 x16535 or email: John.Davey@va.gov
Study Location
Louis Stokes Cleveland Medical Center – Cleveland, OH
Research Objective
The goal of this study is to make upper limb prosthetic devices more natural and useful for Veterans who have lost an upper limb by providing proprioceptive feedback about prosthesis postures and movements. By doing this study we hope to characterize proprioceptive sensations elicited by peripheral nerve stimulation and investigate the mechanisms of stimulation-evoked proprioception. Participants do not need to be local to the Cleveland area.
Eligibility Criteria
- Must be a Veteran of the US military, age 18 or older
- Must have unilateral upper limb amputation above– or below–the–elbow with fully healed and healthy surgical sites.
- Must have viable peripheral nerve function in the residual limb as well as volitional activity of the residual muscles in the amputated limb.
- Must be determined medically fit to undergo anesthesia.
- Must be fitted with a prosthesis by a CPO and have at least one month experience
- using the prosthesis.
- Must be willing and able to follow the study protocol.
Compensation
- $50.00 per day (4-6 hours each day) in the lab once enrolled in the study.
- Travel can also be provided
Enrollment Closes
09/01/2025
Time Commitment
- Trial lasts approximately 18 months
- Participants come to the lab once every 45 days for 1-3 days of testing.
Contact Person
Chris Cowen | Email: Christine.Cowen@va.gov | Phone: 216-791-3800 ext. 63801
How to Participate
Contact Chris Cowen
Study Location
Louis Stokes Cleveland Medical Center – Cleveland, OH
Research Objective
Our research aims to restore sensory feedback and provide volitional prosthetic control to those living with lower limb loss. This requires an outpatient surgical procedure to implant a device that would activate the nerves to produce sensation as if it were arising from the missing foot and record muscle activity which would direct the movement of the prosthetic joint. We are also studying how this technology can impact limb health and potentially slow the progression of vascular illnesses such as those caused by diabetes.
Eligibility Criteria
- Lower limb amputation
- Adults aged 18 or older
- Healthy residual limb
- Absence of autoimmune disorders
Compensation
- $50.00 per day in the lab once enrolled in the study
- Travel and stay expenses can also be provided
Enrollment Closes
Dec 31, 2025
Time Commitment
- Trial lasts approximately 18 months
- Participants come to the Cleveland lab once every 45 days for 1-3 days of testing
Contact Person
Aarika Sheehan PT, DPT | Email: aarika.sheehan@va.gov | Phone: 216-791-3800 ext. 65832
How to Participate
Contact Aarika Sheehan
Study Location
Louis Stokes Cleveland Medical Center – Cleveland, OH
Research Objective
The goal of this study is to understand the critical factors associated with outcome acceptance following upper limb loss and to understand the psychosocial experience of upper limb prosthesis use. We must understand the relationships between prosthesis functional and sensory capabilities, the subjective experience of the prosthesis, and outcome acceptance following limb loss, in order to provide better prosthetic device options and improve rehabilitation outcomes. Study results will enable clinicians and researchers to evaluate and predict patient outcomes following limb loss based on user priorities and to design interventions that improve outcomes.
Eligibility Criteria
- Must be 18 years or older
- Must be able to provide verbal informed consent
- Must be able to speak and understand English
- Must have acquired a single upper limb amputation of the forearm (transradial) or above-the-elbow (transhumeral).
- Amputation must have occurred at least six months prior to study enrollment
- Must be a current or past user of an upper limb prosthesis
- Must have at least six months of experience using a prosthesis
Compensation
- Up to $40 ($20 per phone call)
Enrollment Closes
December 31, 2024
Time Commitment
- Phone Interview (1 hour)
- Phone Survey (1 hour)
Contact Person
Jessica Jarvela | Phone: 216-791-3800 x 63801
How to Participate
See further instructions in the Recruitment Flyer.
Study Location
University of California, San Diego (UCSD) – San Diego, CA
Research Objective
Primary Aim: To test the hypothesis that it is safe and effective to administer psilocybin to individuals who experience phantom limb pain. Secondary aim: To determine behavioral and neural pain responses during noxious stimulation and at rest before and after psilocybin therapy.
Eligibility Criteria
- Between 18 and 75 years of age.
- Must have had an amputation of one extremity (upper or lower limb).
- Experience phantom limb pain (for 1+ months) rated in intensity of at least 3 out of 10.
- Must be fluent in the English language.
- Must adhere to the medication/drug use protocols for the duration of the study (more information can be found on our Clinical Trial Webpage).
- Must tolerate an MRI scan procedure without sedation.
- Women of childbearing potential must agree to practice effective means of birth control throughout the duration of the study.
- Must be accompanied by another individual who can provide transportation to and from the study visits.
Compensation
- $600 (upon completion of all required study visits)
Enrollment Closes
September 1, 2027
Time Commitment
- Approximately 45-60 minutes.
Contact Person
Email: phri-recruitment@ucsd.edu| Phone: 619-432-5278
How to Participate
Please visit our Clinical Trial webpage to speak with a researcher and determine your eligibility.
Study Location
Online Only.
Research Objective
The purpose of this survey is to examine the physical activity and fitness trends of lower limb amputees to establish a benchmark for the population. The goal is to use these results to assist in developing new ideas for patient care.
Eligibility Criteria
- Have lower limb amputation(s) of any-level (i.e. toe, partial foot, Symes, transtibial/ BK, rotationplasty, knee disarticulation, transfemoral/ AK, hip disarticulation, hemipelvectomy).
Compensation
- Not available
Enrollment Closes
December 31, 2024
Time Commitment
- Approximately 15 minutes.
Contact Person
Noah Krichau | Email : nkrichau@emich.edu | Phone: 515-979-8955
How to Participate
Click Here to take the survey. Please contact Noah Krichau if you have any questions regarding this study.
Study Location
Moss Rehabilitation Research Institute – Philadelphia, PA
Research Objective
This study is a randomized controlled trial to determine if virtual reality (VR) treatments can reduce phantom leg pain. Group 1 will test our Active VR treatment (which involves virtual gaming with leg movements and visual feedback of the missing leg). Group 2 will receive a commercially available VR pain treatment (Distractor VR). Our findings will be used to develop and assess the feasibility of a home intervention program using the most efficacious intervention, either Active VR or Distractor VR. MRI imaging will be used in both studies to attempt to identify biomarkers that can predict the efficacy of treatment.
Eligibility Criteria
- Unilateral Above-knee Amputation
- Unilateral Below-knee Amputation
- Experiences Phantom Limb Pain
Compensation
- Up to $180 (12 visits – 8 treatment sessions and 4 questionnaires sessions /$15 per visit)
- Additional $80 (two MRI scans)
- Paid Travel Costs
Enrollment Closes
September 2026
Time Commitment
- 8 twice-weekly VR treatment sessions (1 hour each), 4 sessions of questionnaires (before and after treatment, plus two follow-up sessions).
- Two Magnetic Resonance Imaging (MRI) scans.
Contact Person
Elisabetta Ambron, PhD. | Email : eli.ambron@gmail.com
Research Associate, University of Pennsylvania
How to Participate
See further instructions in the Recruitment Flyer.
Study Location
Spaulding Rehabilitation Hospital – Cambridge, MA
Research Objective
This study is designed to test the effectiveness of a home-based treatment intervention for phantom limb pain. This treatment protocol combines a non-invasive brain stimulation called Transcranial Direct Current Stimulation (tDCS) and somatosensory training in a home-based setting. We will compare patients randomized to this combined strategy vs. usual care alone to examine differences in perceived pain.
Eligibility Criteria
- Have limb amputation(s), any level
- Experience chronic pain of the amputated limb(s)
- Must be at least 18 years of age
Compensation
$345
Enrollment Closes
March 2027
Time Commitment
- 22 visits during the 4-week treatment protocol (1-hour sessions)
- 1 follow-up visit at 8 weeks post-treatment
Contact Person
Spaulding Neuromodulation Center | Email: epichardo@partners.org
How to Participate
See further instructions in the Recruitment Flyer.
The research studies listed on this page have completed all the necessary documentation to assure that the human subject protocols have been approved through a recognized Institutional Review Board and have provided a statement that there are no commercial conflicts of interest. This listing does not imply endorsement of the Amputee Coalition. Research projects are listed as a service to researchers and to our members of the limb loss and limb difference community. The Amputee Coalition is not responsible for the conduct of the researchers. The sponsoring institution assumes responsibility for researcher’s conduct. If you have questions about a study listed on this page or if you would like to determine your enrollment eligibility for a study, please reach out to the Contact Person listed for that study.