Study Title:
Cardiovascular Health and Autonomic Dysfunction in Adults with Lower-Limb Amputation
Study Location:
University of Delaware, 540 S. College Avenue, Newark, DE; Independence Prosthetics-Orthotics, Inc., Newark, Dover, Rehoboth Beach, Wilmington, DE, Philadelphia and Brookhaven, PA, Charlottesville, Fishersville, VA; Dankmeyer Prosthetics-Orthotics, Linthicum, MD; Allied OP, Mt Laurel, Sewell, Toms River, NJ, Philadelphia, Elkins Park, Bethlehem, PA; Real-Life Prosthetics, Abingdon, MD; Medical Center Orthotics & Prosthetics, Silver Spring, MD; Wilmington VA
Research Objectives:
The goal of this study is to explore relationships between heart and blood vessel health and nervous system function after lower-limb amputation.
Eligibility Criteria:
You may be eligible if…
• You have a below-knee amputation, and…
o Are 20-85 years-old.
o Have no history of heart attack, stroke, or heart failure.
o Do not have any amputation of the opposite leg (other than toes).
o Do not have any amputations of your arms (other than fingers).
o Did not have your amputation due to a birth defect and do not use a prosthesis due to limb difference from birth.
You may be eligible if…
• You match an individual with limb amputation and…
o Are 20-85 years-old.
o Have no history of heart attack, stroke, or heart failure.
o Have had no pain in the past week.
Compensation Details:
• Up to $210 in gift cards for completion of Part 1 and Part 2.
• You have the option to participate in Part 1 ($110) and not Part 2 ($100).
Enrollment Closes:
May 31, 2026
Time Commitment:
PART 1:
• < 1 hour Survey Packet (at home)
• < 2 hours Clinical Examination at a local clinic or the University of Delaware
• Wear activity monitors for 7 days
PART 2 (optional): 2-hour Clinical Examination at University of Delaware
Contact Person:
Delaware Limb Loss Studies Lab 302-831-7142
How to Participate:
Please call (302) 831-7142 to be screened for participation.
Provide the URL link to website or survey (optional):